miR-200 Sponge Vector

miR-200 is a family of microRNAs that contains five members including miR-200a, miR-200b, miR-200c, miR-141, and miR-429. The members of miR-200 are located in two different genomic regions. In humans, the Cluster I miR-200s (miR-200b/200a/429) are located on chromosome 1 and cluster II miR-200s (miR-200c/141) are on chromosome 12. In mice, the two clusters are on chromosomes 4 and 6.

The miR-200 family members can also be divided into two functional groups based on their seed sequences. One group consists of miR-200b, -200c, and -429 which share the same seed sequence (AAUACUG), and the other group is composed of miR-141 and -200a that share the same seed sequence (AACACUG). miR-200 is highly conserved among vertebrate species and highly expressed within epithelial cells. There is growing evidence to suggest that members of the miR‑200 family play crucial roles in cancer initiation and metastasis. The miR-200 family is among the most widely studied miRNAs in cancer, and may be important for the diagnosis and serve as novel targets for the therapy of multiple types of cancer.

RGBiotech offers the sponge vector that contains CMV promoter driving expression of mCherry reporter gene and 6 tandem repeats of sponge sequences targeting against murine miR-200 family. For more information, please contact us at admin@rgbiotech.com.

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