CEACAM5 scFv-CD28-OX40-CD3ζ (3rd) CAR Expression Plasmid

INTRODUCTION

Chimeric Antigen Receptors (CARs) are recombinant receptors that are composed of four regions: an antigen recognition domain (ectodomain), a hinge region, a transmembrane region, and an intracellular T cell signaling domain (endodomain). CAR-T cell therapy uses T cells engineered with CARs to target specific antigen(s) for cancer immunotherapy.

Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), also known as Cluster of Differentiation 66e (CD66e), is a cell surface glycoprotein that belongs to a member of the carcinoembryonic antigen (CEA) family of proteins. CEACAM5 is often used as a clinical biomarker for many types of malignancies. It functions as a cell adhesion molecule and plays important roles in the inhibition of differentiation and apoptosis in colon cells. CEACAM5 protein is a target of chimeric antigen receptor (CAR) T-cells used in the treatment of relapsed/refractory CEA+ cancers.

RGBiotech offers CEACAM5 scFv-CD28-OX40-CD3ζ (3rd) CAR Expression Plasmid to assist CAR-T research. This vector contains a third (3rd) generation of CEACAM5 CAR that consists of four major components: 1) anti-CEACAM5 scFv as an extracellular antigen-binding domain, 2) a hinge region, 3) a transmembrane domain, and 4) CD28, OX40 (TNFRSF4, CD134) and CD3ζ (CDzeta, CD247) intracellular signaling domains.

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