CS1 scFv-CD28-OX40-CD3ζ (3rd) CAR Expression Plasmid

INTRODUCTION

Chimeric Antigen Receptors (CARs) are recombinant receptors that are composed of four regions: an antigen recognition domain (ectodomain), a hinge region, a transmembrane region, and an intracellular T cell signaling domain (endodomain). CAR-T cell therapy uses T cells engineered with CARs to target specific antigen(s) for cancer immunotherapy.

CS1 (also known as SLAMF7 and CD319) is a robust protein marker of normal plasma cells and malignant plasma cells in multiple myeloma. It may be involved in adaptive immune response and regulation of natural killer cell activation. CS1 protein is a target of chimeric antigen receptor (CAR) T-cells used in the treatment of myeloma.

RGBiotech offers CS1 scFv-CD28-OX40-CD3ζ (3rd) CAR Expression Plasmid to assist CAR-T research. This vector contains a third (3rd) generation of CS1 CAR that consists of four major components: 1) anti-CS1 scFv as an extracellular antigen-binding domain, 2) a hinge region, 3) a transmembrane domain, and 4) CD28, OX40 (TNFRSF4, CD134) and CD3ζ (CDzeta, CD247) intracellular signaling domains.

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APPLICATIONS

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