CD1A scFv-CD28-OX40-CD3ζ (3rd) CAR Expression Plasmid

INTRODUCTION

Chimeric Antigen Receptors (CARs) are recombinant receptors that are composed of four regions: an antigen recognition domain (ectodomain), a hinge region, a transmembrane region, and an intracellular T cell signaling domain (endodomain). CAR-T cell therapy uses T cells engineered with CARs to target specific antigen(s) for cancer immunotherapy.

CD1A (Cluster of Differentiation 1A) is a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. CD1A protein localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Expression of CD1A is upregulated in the lung parenchyma of smokers. CD1A protein is a target of chimeric antigen receptor (CAR) T-cells used in the treatment of CD1A-positive cortical T-ALL (T cell acute lymphoblastic leukemia).

RGBiotech offers CD1A scFv-CD28-OX40-CD3ζ (3rd) CAR Expression Plasmid to assist CAR-T research. This vector contains a third (3rd) generation of CD1A CAR that consists of four major components: 1) anti-CD1A scFv as an extracellular antigen-binding domain, 2) a hinge region, 3) a transmembrane domain, and 4) CD28, OX40 (TNFRSF4, CD134) and CD3ζ (CDzeta, CD247) intracellular signaling domains.

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