INTRODUCTION

[Antihemophilic factor, human recombinant] (brand names Advate, Adynovate, Helixate, Kogenate, Kovaltry, Novoeight, Recombinate), is glycosylated, recombinant human antihemophilic factor (AHF) or coagulation Factor VIII which is composed of 2332 amino acids and is used in the treatment of hemophilia A, von Willebrand disease, and Factor XIII deficiency.

This plasmid is designed for expressing [Antihemophilic factor, human recombinant] in Chinese hamster ovary (CHO) cell line.

PRODUCT INFORMATION

Item No.: PPBD-23
Shipping: Lyophilized plasmid, or liquid plasmid, or plasmids on filter paper
Storage: -20 °C or 4°C according to instruction
Plasmid Backbone: Expression plasmid, flexible options, custom available
Quality Control: Sequencing validation

DRUG INFORMATION

Generic Name: Antihemophilic factor, human recombinant
Brand Names: Advate, Adynovate, Helixate, Kogenate, Kovaltry, Novoeight, Recombinate
Classification: Blood factors
Amino Acid Sequence: Identical to DB00025

PROTOCOL FOR PLASMID RECOVERY FROM FILTER PAPER

REFERENCE

[1]Gouw SC, van der Bom JG, Auerswald G, Ettinghausen CE, Tedgård U, van den Berg HM. Recombinant versus plasma-derived factor VIII products and the development of inhibitors in previously untreated patients with severe hemophilia A: the CANAL cohort study. Blood. 2007 Jun 1;109(11):4693-7.

[2] Lusher J, Abildgaard C, Arkin S, Mannucci PM, Zimmermann R, Schwartz L, Hurst D. Human recombinant DNA-derived antihemophilic factor in the treatment of previously untreated patients with hemophilia A: final report on a hallmark clinical investigation. J Thromb Haemost. 2004 Apr;2(4):574-83.

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