INTRODUCTION

Drotrecogin alfa (brand name Xigris) is a recombinant activated human protein C consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa has anti-thrombotic, anti-inflammatory, and profibrinolytic properties and is used to reduce mortality in patients with severe sepsis by inhibiting coagulation Factors V and VIII.

This plasmid is designed for expressing Drotrecogin alfa in mammalian expression system.

PRODUCT INFORMATION

Item No.: PPBD-61
Shipping: Lyophilized plasmid, or liquid plasmid, or plasmids on filter paper
Storage: -20 °C or 4°C according to instruction
Plasmid Backbone: Expression plasmid, flexible options for promoter and selection marker, custom available
Quality Control: Sequencing validation

DRUG INFORMATION

Generic Name: Drotrecogin alfa
Brand Name(s): Xigris
Classification: Other protein based therapies, serine proteases
Amino Acid Sequence: Identical to DB00055

PROTOCOL FOR PLASMID RECOVERY FROM FILTER PAPER

REFERENCE

Martí-Carvajal AJ, Solà I, Gluud C, Lathyris D, Cardona AF. Human recombinant protein C for severe sepsis and septic shock in adult and paediatric patients. Cochrane Database Syst Rev. 2012 Dec 12;12(12):CD004388.

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