INTRODUCTION

Ecallantide (brand name Kalbitor) is a potent and selective inhibitor of human plasma kallikrein that is used to prevent and treat acute attacks caused by hereditary angioedema (HAE).

This plasmid is designed for expressing Ecallantide in Pichia pastoris yeast expression system.

PRODUCT INFORMATION

Item No.: PPBD-65
Shipping: Lyophilized plasmid, or liquid plasmid, or plasmids on filter paper
Storage: -20 °C or 4°C according to instruction
Plasmid Backbone: Expression plasmid, flexible options, custom available
Quality Control: Sequencing validation

DRUG INFORMATION

Generic Name: Ecallantide
Brand Name(s): Kalbitor
Classification: Other protein based therapies
Amino Acid Sequence: Identical to DB05311

PROTOCOL FOR PLASMID RECOVERY FROM FILTER PAPER

REFERENCE

[1] Lehmann A. Ecallantide (DX-88), a plasma kallikrein inhibitor for the treatment of hereditary angioedema and the prevention of blood loss in on-pump cardiothoracic surgery. Expert Opin Biol Ther. 2008 Aug;8(8):1187-99.

[2] Farkas H, Varga L. Ecallantide is a novel treatment for attacks of hereditary angioedema due to C1 inhibitor deficiency. Clin Cosmet Investig Dermatol. 2011;4:61-8.

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