INTRODUCTION

Fremanezumab (brand name Ajovy) is a humanized monoclonal antibody that targets calcitonin gene-related peptides (CGRP) alpha and beta. Fremanezumab is used for the prevention of migraine headaches.

This plasmid is designed for expressing Fremanezumab in mammalian expression system such as HEK293 or Chinese hamster ovary (CHO) cell line.

PRODUCT INFORMATION

Item No.: PPBD-79
Shipping: Lyophilized plasmid, or liquid plasmid, or plasmids on filter paper
Storage: -20 °C or 4°C according to instruction
Plasmid Backbone: Expression plasmid, flexible options for promoter and selection marker, custom available
Quality Control: Sequencing validation

DRUG INFORMATION

Generic Name: Fremanezumab
Brand Name(s): Ajovy
Classification: Monoclonal antibody (mAb)
Target: Calcitonin gene-related peptide (CGRP) α, β
Amino Acid Sequence: Identical to DB14041

PROTOCOL FOR PLASMID RECOVERY FROM FILTER PAPER

REFERENCE

[1] Pellesi L, Guerzoni S, Pini LA. Spotlight on Anti-CGRP Monoclonal Antibodies in Migraine: The Clinical Evidence to Date. Clin Pharmacol Drug Dev. 2017 Nov;6(6):534-547.

[2] Vollbracht S, Rapoport AM. New treatments for headache. Neurol Sci. 2014 May;35 Suppl 1:89-97.

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