INTRODUCTION

Glucarpidase (brand name Voraxaze) is a recombinant bacterial enzyme carboxypeptidase G2 that is used for reducing plasma concentrations of methotrexate in patients suffering impaired renal function.

This plasmid is designed for expressing Glucarpidase in E.coli expression system.

PRODUCT INFORMATION

Item No.: PPBD-85
Shipping: Lyophilized plasmid, or liquid plasmid, or plasmids on filter paper
Storage: -20 °C or 4°C according to instruction
Plasmid Backbone: Expression plasmid, flexible options, custom available
Quality Control: Sequencing validation

DRUG INFORMATION

Generic Name: Glucarpidase
Brand Name(s): Voraxaze
Classification: Recombinant Enzyme
Amino Acid Sequence: Identical to DB08898

PROTOCOL FOR PLASMID RECOVERY FROM FILTER PAPER

REFERENCE

[1] Green JM. Glucarpidase to combat toxic levels of methotrexate in patients. Ther Clin Risk Manag. 2012;8:403-13.

[2] Tuffaha HW, Al Omar S. Glucarpidase for the treatment of life-threatening methotrexate overdose. Drugs Today (Barc). 2012 Nov;48(11):705-11.

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