INTRODUCTION

Guselkumab (brand name Tremfya) is a human immunoglobulin G1 lambda (IgG1λ) monoclonal antibody that binds to interleukin-23 (IL-23). Guselkumab is used to treat moderate to severe plaque psoriasis.

This plasmid is designed for expressing Guselkumab in mammalian expression system such as HEK293 or Chinese hamster ovary (CHO) cell line.

PRODUCT INFORMATION

Item No.: PPBD-86
Shipping: Lyophilized plasmid, or liquid plasmid, or plasmids on filter paper
Storage: -20 °C or 4°C according to instruction
Plasmid Backbone: Expression plasmid, flexible options for promoter and selection marker, custom available
Quality Control: Sequencing validation

DRUG INFORMATION

Generic Name: Guselkumab
Brand Name(s): Tremfya
Classification: Monoclonal antibody (mAb)
Target: interleukin-23 (IL-23)
Amino Acid Sequence: Identical to DB11834

PROTOCOL FOR PLASMID RECOVERY FROM FILTER PAPER

REFERENCE

Sofen H, Smith S, Matheson RT, Leonardi CL, Calderon C, Brodmerkel C, Li K, Campbell K, Marciniak SJ Jr, Wasfi Y, Wang Y, Szapary P, Krueger JG. Guselkumab (an IL-23-specific mAb) demonstrates clinical and molecular response in patients with moderate-to-severe psoriasis. J Allergy Clin Immunol. 2014 Apr;133(4):1032-40.

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