INTRODUCTION

Idarucizumab (brand name Praxbind) is a humanized monoclonal antibody fragment (Fab) that targets to dabigatran. Idarucizumab is used as a reversal agent for dabigatran.

This plasmid is designed for expressing Idarucizumab in mammalian expression system such as HEK293 or Chinese hamster ovary (CHO) cell line.

PRODUCT INFORMATION

Item No.: PPBD-92
Shipping: Lyophilized plasmid, or liquid plasmid, or plasmids on filter paper
Storage: -20 °C or 4°C according to instruction
Plasmid Backbone: Expression plasmid, flexible options for promoter and selection marker, custom available
Quality Control: Sequencing validation

DRUG INFORMATION

Generic Name: Idarucizumab
Brand Name(s): Praxbind
Classification: Monoclonal antibody (mAb)
Target: dabigatran
Amino Acid Sequence: Identical to DB09264

PROTOCOL FOR PLASMID RECOVERY FROM FILTER PAPER

REFERENCE

[1] Syed YY. Idarucizumab: A Review as a Reversal Agent for Dabigatran. Am J Cardiovasc Drugs. 2016 Aug;16(4):297-304.

[2] Yogaratnam D, Ditch K, Medeiros K, Doyno C, Fong JJ. Idarucizumab for Reversal of Dabigatran-Associated Anticoagulation. Ann Pharmacother. 2016 Oct;50(10):847-54.

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