INTRODUCTION

Idursulfase (brand name Elaprase) is a recombinant lysosomal enzyme that is used as a replacement therapy for the treatment of Hunter syndrome (also called MPS-II) in patients.

This plasmid is designed for expressing Idursulfase in mammalian expression system such as HEK293 or Chinese hamster ovary (CHO) cell line.

PRODUCT INFORMATION

Item No.: PPBD-93
Shipping: Lyophilized plasmid, or liquid plasmid, or plasmids on filter paper
Storage: -20 °C or 4°C according to instruction
Plasmid Backbone: Expression plasmid, flexible options for promoter and selection marker, custom available
Quality Control: Sequencing validation

DRUG INFORMATION

Generic Name: Idursulfase
Brand Name(s): Elaprase
Classification: Recombinant Enzymes
Action Type: Replacement therapy
Amino Acid Sequence: Identical to DB01271

PROTOCOL FOR PLASMID RECOVERY FROM FILTER PAPER

REFERENCE

[1] Zareba G. Idursulfase in Hunter syndrome treatment. Drugs Today (Barc). 2007 Nov;43(11):759-67.

[2] Burrow TA, Leslie ND. Review of the use of idursulfase in the treatment of mucopolysaccharidosis II. Biologics. 2008 Jun;2(2):311-20.

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