INTRODUCTION

Ipilimumab (brand name Yervoy) is a human monoclonal antibody (mAb) that is used to treat metastatic or unresectable melanoma by blocking cytotoxic T-lymphocyte antigen 4 (CTLA-4).

This plasmid is designed for expressing Ipilimumab in mammalian expression system such as HEK293 or Chinese hamster ovary (CHO) cell line.

PRODUCT INFORMATION

Item No.: PPBD-111
Shipping: Lyophilized plasmid, or liquid plasmid, or plasmids on filter paper
Storage: -20 °C or 4°C according to instruction
Plasmid Backbone: Expression plasmid, flexible options for promoter and selection marker, custom available
Quality Control: Sequencing validation

DRUG INFORMATION

Generic Name: Ipilimumab
Brand Name(s): Yervoy
Classification: Monoclonal antibody (mAb)
Target: cytotoxic T-lymphocyte associated protein 4 (CTLA-4)
Amino Acid Sequence: Identical to DB06186

PROTOCOL FOR PLASMID RECOVERY FROM FILTER PAPER

REFERENCE

[1] Johnson DB, Peng C, Abramson RG, Ye F, Zhao S, Wolchok JD, Sosman JA, Carvajal RD, Ariyan CE. Clinical Activity of Ipilimumab in Acral Melanoma: A Retrospective Review. Oncologist. 2015 Jun;20(6):648-52.

[2] Thumar JR, Kluger HM. Ipilimumab: a promising immunotherapy for melanoma. Oncology (Williston Park). 2010 Dec;24(14):1280-8.

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