INTRODUCTION

Olaratumab (brand name Lartruvo) is a human monoclonal antibody (mAb) that binds to platelet-derived growth factor receptor alpha (PDGF-R α). Olaratumab is used in the treatment of solid tumors.

This plasmid is designed for expressing Olaratumab in mammalian expression system such as HEK293 or Chinese hamster ovary (CHO) cell line.

PRODUCT INFORMATION

Item No.: PPBD-131
Shipping: Lyophilized plasmid, or liquid plasmid, or plasmids on filter paper
Storage: -20 °C or 4°C according to instruction
Plasmid Backbone: Expression plasmid, flexible options for promoter and selection marker, custom available
Quality Control: Sequencing validation

DRUG INFORMATION

Generic Name: Olaratumab
Brand Name(s): Lartruvo
Classification: Monoclonal antibody (mAb)
Target: PDGF-R α
Amino Acid Sequence: Identical to DB06043

PROTOCOL FOR PLASMID RECOVERY FROM FILTER PAPER

REFERENCE

[1] Dolloff NG, Russell MR, Loizos N, Fatatis A. Human bone marrow activates the Akt pathway in metastatic prostate cells through transactivation of the alpha-platelet-derived growth factor receptor. Cancer Res. 2007 Jan 15;67(2):555-62.

[2] Doi T, Ma Y, Dontabhaktuni A, Nippgen C, Nippgen J, Ohtsu A. Phase I study of olaratumab in Japanese patients with advanced solid tumors. Cancer Sci. 2014 Jul;105(7):862-9.

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