INTRODUCTION

Omalizumab (brand name Xolair) is a humanized IgG1 monoclonal antibody that bings to immunoglobulin E (IgE). Omalizumab is used in the treatment of severe asthma and chronic idiopathic urticaria.

This plasmid is designed for expressing Omalizumab in mammalian expression system such as HEK293 or Chinese hamster ovary (CHO) cell line.

PRODUCT INFORMATION

Item No.: PPBD-132
Shipping: Lyophilized plasmid, or liquid plasmid, or plasmids on filter paper
Storage: -20 °C or 4°C according to instruction
Plasmid Backbone: Expression plasmid, flexible options for promoter and selection marker, custom available
Quality Control: Sequencing validation

DRUG INFORMATION

Generic Name: Omalizumab
Brand Name(s): Xolair
Classification: Monoclonal antibody (mAb)
Target: immunoglobulin E, IgE
Amino Acid Sequence: Identical to DB00043

PROTOCOL FOR PLASMID RECOVERY FROM FILTER PAPER

REFERENCE

[1] Jensen RK, Plum M, Tjerrild L, Jakob T, Spillner E, Andersen GR. Structure of the omalizumab Fab. Acta Crystallogr F Struct Biol Commun. 2015 Apr;71(Pt 4):419-26.

[2] Miller CW, Krishnaswamy N, Johnston C, Krishnaswamy G. Severe asthma and the omalizumab option. Clin Mol Allergy. 2008 May 20;6:4.

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