INTRODUCTION

Romiplostim (brand name Nplate) is a fusion protein analog of thrombopoietin (TPO) that can recognize and activate the TPO receptor to increase platelet production. Romiplostim is used to treat thrombocytopenia associated with chronic immune thrombocytopenia (ITP).

RGBiotech offers Romiplostim Expression Plasmid. This plasmid is designed for expressing Romiplostim in E.coli expression system.

PRODUCT INFORMATION

Item No.: PPBD-162
Shipping: Lyophilized plasmid, or liquid plasmid, or plasmids on filter paper
Storage: -20 °C or 4°C according to instruction
Plasmid Backbone: Expression plasmid, flexible options, custom available
Quality Control: Sequencing validation

DRUG INFORMATION

Generic Name: Romiplostim
Brand Name(s): Nplate
Classification: Haematopoietic growth factors
Amino Acid Sequence: Identical to DB05332

PROTOCOL FOR PLASMID RECOVERY FROM FILTER PAPER

REFERENCE

[1] Kumagai Y, Fujita T, Ozaki M, Sahashi K, Ohkura M, Ohtsu T, Arai Y, Sonehara Y, Nichol JL. Pharmacodynamics and pharmacokinetics of AMG 531, a thrombopoiesis-stimulating peptibody, in healthy Japanese subjects: a randomized, placebo-controlled study. J Clin Pharmacol. 2007 Dec;47(12):1489-97.

[2] Rice L. Drug evaluation: AMG-531 for the treatment of thrombocytopenias. Curr Opin Investig Drugs. 2006 Sep;7(9):834-41.

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