INTRODUCTION

Sebelipase alfa (brand name Leukine) is a recombinant lysosomal acid lipase (LAL) that is used for the treatment of lysosomal acid lipase deficiency (LAL-D).

RGBiotech offers Sebelipase alfa Expression Plasmid. This plasmid is designed for expressing Sebelipase alfa in mammalian expression system such as HEK293 or CHO-K1 cells.

PRODUCT INFORMATION

Item No.: PPBD-166
Shipping: Lyophilized plasmid, or liquid plasmid, or plasmids on filter paper
Storage: -20 °C or 4°C according to instruction
Plasmid Backbone: Expression plasmid, flexible options, custom available
Quality Control: Sequencing validation

DRUG INFORMATION

Generic Name: Sebelipase alfa
Brand Name(s): Kanuma
Classification: Recombinant Enzymes
Amino Acid Sequence: Identical to DB11563

PROTOCOL FOR PLASMID RECOVERY FROM FILTER PAPER

REFERENCE

[1] Burton BK, Balwani M, Feillet F, Barić I, Burrow TA, Camarena Grande C, Coker M, Consuelo-Sánchez A, Deegan P, Di Rocco M, Enns GM, Erbe R, Ezgu F, Ficicioglu C, Furuya KN, Kane J, Laukaitis C, Mengel E, Neilan EG, Nightingale S, Peters H, Scarpa M, Schwab KO, Smolka V, Valayannopoulos V, Wood M, Goodman Z, Yang Y, Eckert S, Rojas-Caro S, Quinn AG. A Phase 3 Trial of Sebelipase Alfa in Lysosomal Acid Lipase Deficiency. N Engl J Med. 2015 Sep 10;373(11):1010-20.

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