INTRODUCTION

Tenecteplase (brand names Metalyse, Tnkase) is a recombinant human tissue plasminogen activator (tPA) used as a thrombolytic drug in the emergency treatment of myocardial infarction and pulmonary emboli.

RGBiotech offers Tenecteplase expression plasmid vector. This plasmid vector is designed for expressing Tenecteplase in mammalian CHO (Chinese hamster ovary) cell expression system .

PRODUCT INFORMATION

Item No.: PPBD-178
Shipping: Lyophilized plasmid, or liquid plasmid, or plasmids on filter paper
Storage: -20 °C or 4°C according to instruction
Plasmid Backbone: Expression plasmid, flexible options, custom available
Quality Control: Sequencing validation

DRUG INFORMATION

Generic Name: Tenecteplase
Brand Name(s): Metalyse, Tnkase
Amino Acid Sequence: Identical to DB00031

PROTOCOL FOR PLASMID RECOVERY FROM FILTER PAPER

REFERENCE

[1] Gurbel PA, Hayes K, Bliden KP, Yoho J, Tantry US. The platelet-related effects of tenecteplase versus alteplase versus reteplase. Blood Coagul Fibrinolysis. 2005 Jan;16(1):1-7.

[2] Melzer C, Richter C, Rogalla P, Borges AC, Theres H, Baumann G, Laule M: Tenecteplase for the treatment of massive and submassive pulmonary embolism. J Thromb Thrombolysis. 2004 Aug;18(1):47-50.

[3] Ohman EM, Van de Werf F, Antman EM, Califf RM, de Lemos JA, Gibson CM, Oliverio RL, Harrelson L, McCabe C, DiBattiste P, Braunwald E: Tenecteplase and tirofiban in ST-segment elevation acute myocardial infarction: results of a randomized trial. Am Heart J. 2005 Jul;150(1):79-88.

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