INTRODUCTION

Tositumomab is a mouse IgG2a-lambda monoclonal antibody that binds to CD20 and is used to treat B-cell non-Hodgkin's lymphoma via a conjugated radioactive isotope.

RGBiotech offers Tositumomab expression plasmid vector. This plasmid vector is designed for expressing Tositumomab in mammalian expression system such as HEK293 or Chinese hamster ovary (CHO) cell line.

PRODUCT INFORMATION

Item No.: PPBD-187
Shipping: Lyophilized plasmid, or liquid plasmid, or plasmids on filter paper
Storage: -20 °C or 4°C according to instruction
Plasmid Backbone: Expression plasmid, flexible options, custom available
Quality Control: Sequencing validation

DRUG INFORMATION

Generic Name: Tositumomab
Classification: Monoclonal antibody (mAb)
Target: MS4A1, B1; S7; Bp35; CD20; FMC7; CVID5; LEU-16
Amino Acid Sequence: Identical to DB00081

PROTOCOL FOR PLASMID RECOVERY FROM FILTER PAPER

REFERENCE

[1] Srinivasan A, Mukherji SK. Tositumomab and iodine I 131 tositumomab (Bexaar). AJNR Am J Neuroradiol. 2011 Apr;32(4):637-8..

[2] Davies AJ. Radioimmunotherapy for B-cell lymphoma: Y90 ibritumomab tiuxetan and I(131) tositumomab. Oncogene. 2007 May 28;26(25):3614-28.

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