INTRODUCTION

Turoctocog alfa (brand name Recothrom) is a recombinant antihemorrhagic factor VIII (rFVIII) that is used for the treatment and prophylaxis of bleeding in patients with haemophilia A (congenital factor VIII deficiency).

RGBiotech offers Turoctocog alfa expression plasmid vector. This plasmid vector is designed for expressing Turoctocog alfa in mammalian Chinese Hamster Ovary (CHO) cell expression system .

PRODUCT INFORMATION

Item No.: PPBD-189
Shipping: Lyophilized plasmid, or liquid plasmid, or plasmids on filter paper
Storage: -20 °C or 4°C according to instruction
Plasmid Backbone: Expression plasmid, flexible options, custom available
Quality Control: Sequencing validation

DRUG INFORMATION

Generic Name: Turoctocog alfa
Brand Name(s): Novoeight, Zonovate
Classification: Blood factors
Amino Acid Sequence: Identical to DB09109

PROTOCOL FOR PLASMID RECOVERY FROM FILTER PAPER

REFERENCE

[1] Ezban M, Vad K, Kjalke M. Turoctocog alfa (NovoEight®)--from design to clinical proof of concept. Eur J Haematol. 2014 Nov;93(5):369-76.

[2] Agersø H, Stennicke HR, Pelzer H, Olsen EN, Merricks EP, Defriess NA, Nichols TC, Ezban M. Pharmacokinetics and pharmacodynamics of turoctocog alfa and N8-GP in haemophilia A dogs. Haemophilia. 2012 Nov;18(6):941-7.

[3] Takedani H, Hirose J. Turoctocog alfa: an evidence-based review of its potential in the treatment of hemophilia A. Drug Des Devel Ther. 2015 Mar 24;9:1767-72.

Contact Us