INTRODUCTION

Alglucosidase alfa (brand name Lumizyme, Myozyme) is a recombinant enzyme that is used for the treatment of Pompe disease in infants and pediatric patients caused by GAA deficiency.

This plasmid is designed for expressing Alglucosidase alfa in Chinese hamster ovary (CHO) cell line.

PRODUCT INFORMATION

Item No.: PPBD-16
Shipping: Lyophilized plasmid, or liquid plasmid, or plasmids on filter paper
Storage: -20 °C or 4°C according to instruction
Plasmid Backbone: Expression plasmid, flexible options for promoter and antibiotic selection marker, custom available
Quality Control: Sequencing validation

DRUG INFORMATION

Generic Name: Alglucosidase alfa
Brand Names: Lumizyme, Myozyme
Classification: Recombinant Enzymes
Amino Acid Sequence: Identical to DB01272

PROTOCOL FOR PLASMID RECOVERY FROM FILTER PAPER

REFERENCE

Kishnani PS, Corzo D, Nicolino M, Byrne B, Mandel H, Hwu WL, Leslie N, Levine J, Spencer C, McDonald M, Li J, Dumontier J, Halberthal M, Chien YH, Hopkin R, Vijayaraghavan S, Gruskin D, Bartholomew D, van der Ploeg A, Clancy JP, Parini R, Morin G, Beck M, De la Gastine GS, Jokic M, Thurberg B, Richards S, Bali D, Davison M, Worden MA, Chen YT, Wraith JE. Recombinant human acid [alpha]-glucosidase: major clinical benefits in infantile-onset Pompe disease. Neurology. 2007 Jan 9;68(2):99-109.

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