Kinase Expression Plasmid Vectors

Kinase is an enzyme that catalyzes the transfer of phosphate groups from ATP to serine, threonine, or tyrosine residues. The human genome contains over 500 kinase genes. The complete set of protein kinases encoded in the genome is termed as kinome. Most kinases play critical roles in promoting cell proliferation, survival and migration. Kinase constitutive overexpression, or kinase activation induced by mutation, are associated with human cancer initiation, promotion, progression as well as recurrence. Kinases have become a significant group of drug targets. Many kinase-specific inhibitors have received FDA approval for the treatment of various types of cancers. Furthermore, several kinase-targeted drugs are in preclinical stage of drug development or clinical phase trials. Key oncogenic kinase drug targets include epidermal growth factor receptor (EGFR), ERBB2, BCR-ABL, EML4-ALK, ETV6, FGFR2-BICC1, FLT3-ITD, KRAS, MET etc.

RGBiotech offers a series of kinase expression plasmid vectors products that cover the most popular kinase genes driven by different promoters and contain flexible selection markers to facilitate your cell kinome research.

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