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| Home -> Products & Services -> Cell Immortalization Plasmid Vectors -> Bmi1 Expression Plasmid Vector | ||
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Bmi1 Expression Plasmid Vector Item No.: PIM-013Shipping: 4 μg Storage: -20°C BMI1 proto-oncogene, polycomb ring finger (BMI1), also known as PCGF4, RNF51, FLVI2/BMI1, flvi-2/bmi-1 in human, is a ring finger protein that is a member of the polycomb group complex 1 (PRC1) which can repress multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. BMI1 belongs to an oncogene and its aberrant expression is often associated with various types of cancers. Primary cells immortalized by Bmi1 can avoid molecular changes induced by viral oncogenes (e.g., HPV E6/E7, SV40 T antigen) and remain the differentiation ability. A variety of immortalized human epithelial cells and non-epithelial cells have been successfully established by introduction of the Bmi1 gene. RGBiotech provides various types of plasmid vectors expressing human or mouse BMI1 to assist your scientific research work in the field of primary cell immortalization. Please contact us for more product information as well as the price. Highlights -Our large collection of empty vector backbones can always allow you to find the fit-for-project plasmid vectors.-Sequencing validation to make sure zero mutation, -Competitive price APPlications -Production of viral particles by packaging viral-based plasmid vectors-Generation of immortalized cell line References [1] Tan JJ, Wang L, Mo TT, Dai YF, Lu J, Liu X, Chen HH, Tian WD, Li XP. Establishment of Immortalized Laryngeal Epithelial Cells Transfected with Bmi1. Cell Transplant. 2020 Jan-Dec;29:963689720908198.[2] Tátrai P, Szepesi Á, Matula Z, Szigeti A, Buchan G, Mádi A, Uher F, Német K. Combined introduction of Bmi-1 and hTERT immortalizes human adipose tissue-derived stromal cells with low risk of transformation. Biochem Biophys Res Commun. 2012 May 25;422(1):28-35. [3] Dimri GP, Martinez JL, Jacobs JJ, Keblusek P, Itahana K, Van Lohuizen M, Campisi J, Wazer DE, Band V. The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Cancer Res. 2002 Aug 15;62(16):4736-45. [4] Liu S, Wu M, Lancelot M, Deng J, Gao Y, Roback JD, Chen T, Cheng L. BMI1 enables extensive expansion of functional erythroblasts from human peripheral blood mononuclear cells. Mol Ther. 2021 May 5;29(5):1918-1932. [5] Yao S, Tan L, Chen H, Huang X, Zhao W, Wang Y. Potential Research Tool of Stem Cells from Human Exfoliated Deciduous Teeth: Lentiviral Bmi-1 Immortalization with EGFP Marker. Stem Cells Int. 2019 Mar 10;2019:3526409. [6] Yip YL, Pang PS, Deng W, Tsang CM, Zeng M, Hau PM, Man C, Jin Y, Yuen AP, Tsao SW. Efficient immortalization of primary nasopharyngeal epithelial cells for EBV infection study. PLoS One. 2013 Oct 22;8(10):e78395. |
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