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Home -> Products & Services -> Cell Immortalization Plasmid Vectors -> CDK4 Expression Plasmid Vector
 
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CDK4 Expression Plasmid Vector

Item No.: PIM-007
Shipping: 4 μg
Storage: -20°C

Human cyclin dependent kinase 4 (CDK4), also known as CMM3, PSK-J3, is an enzyme and belongs to the cyclin-dependent kinase family. CDK4 a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. Mutations in CDK4 as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb have been proved to be associated with tumorigenesis of many cancers. Previous studies showed that introduction of CDK4 can be used for inducing immortalization of primary cells.

RGBiotech provides various types of plasmid vectors expressing human or mouse CDK4 to assist your scientific research work in the field of primary cell immortalization. Please contact us for more product information as well as the price.

Highlights

-Our large collection of empty vector backbones can always allow you to find the fit-for-project plasmid vectors.
-Sequencing validation to make sure zero mutation,
-Competitive price

APPlications

-Production of viral particles by packaging viral-based plasmid vectors
-Generation of immortalized cell line

References

[1] Nishiwaki M, Toyoda M, Oishi Y, Ishida S, Horiuchi SI, Makino-Itou H, Kimura T, Ohno SI, Ohkura T, Enosawa S, Akutsu H, Nakazawa A, Kasahara M, Kiyono T, Umezawa A. Immortalization of human hepatocytes from biliary atresia with CDK4R24C, cyclin D1, and TERT for cytochrome P450 induction testing. Sci Rep. 2020 Oct 15;10(1):17503.

 

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