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| Home -> Products & Services -> Cell Immortalization Plasmid Vectors -> HOXA9 Expression Plasmid Vector | ||
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HOXA9 Expression Plasmid Vector Item No.: PIM-009Shipping: 4 μg Storage: -20°C Homeobox A9 (HOXA9), also known as HOX1, ABD-B, HOX1G, HOX1.7 in human, is a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. HOXA9 is preferentially expressed in hematopoietic stem cells (HSCs), and is down-regulated when the cell differentiates and matures further. HOXA9 has been shown to interact with MEIS1, PBX2 and TRIP6. Dysregulated expression of HOXA9 can results in acute myeloid leukemia (AML). HOXA9 has been used to immortalize hematopoietic cells. The interaction of HOXA9, HOXB8, and HOXA10 with Pbx1 and Meis1 is essential for immortalization and differentiation of myeloid progenitors. RGBiotech provides various types of plasmid vectors expressing human or mouse HOXB9 to assist your scientific research work in the field of primary cell immortalization. Please contact us for more product information as well as the price. Highlights -Our large collection of empty vector backbones can always allow you to find the fit-for-project plasmid vectors.-Sequencing validation to make sure zero mutation, -Competitive price APPlications -Production of viral particles by packaging viral-based plasmid vectors-Generation of immortalized cell line References [1] Schnabel CA, Jacobs Y, Cleary ML. HoxA9-mediated immortalization of myeloid progenitors requires functional interactions with TALE cofactors Pbx and Meis. Oncogene. 2000 Feb 3;19(5):608-16.[2] Calvo KR, Sykes DB, Pasillas M, Kamps MP. Hoxa9 immortalizes a granulocyte-macrophage colony-stimulating factor-dependent promyelocyte capable of biphenotypic differentiation to neutrophils or macrophages, independent of enforced meis expression. Mol Cell Biol. 2000 May;20(9):3274-85. [3] Ayton PM, Cleary ML. Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9. Genes Dev. 2003 Sep 15;17(18):2298-307. [4] Calvo KR, Sykes DB, Pasillas M, Kamps MP. Hoxa9 immortalizes a granulocyte-macrophage colony-stimulating factor-dependent promyelocyte capable of biphenotypic differentiation to neutrophils or macrophages, independent of enforced meis expression. Mol Cell Biol. 2000 May;20(9):3274-85. |
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