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| Home -> Products & Services -> Cell Immortalization Plasmid Vectors -> KRAS-Mutant Expression Plasmid Vector | ||
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KRAS-Mutant Expression Plasmid Vector Item No.: PIM-012Shipping: 4 μg Storage: -20°C KRAS proto-oncogene, GTPase (KRAS), also known as [NS, NS3, OES, CFC2, RALD, K-Ras, KRAS1, KRAS2, RASK2, KI-RAS, C-K-RAS, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, K-Ras 2, C-K-RAS, c-Ki-ras, c-Ki-ras2] in human, a protein that is a member of the small GTPase superfamily. KRAS mutations occur in a significant of human cancers. Mutant KRAS can increase TERT expression and telomerase activities by activating the RAS–MEK pathway. KRAS-Mutant (like G12V or G12D) can be used for primary cell immortalization. RGBiotech provides various types of plasmid vectors expressing human or mouse MYC to assist your scientific research work in the field of primary cell immortalization. Please contact us for more product information as well as the price. Highlights -Our large collection of empty vector backbones can always allow you to find the fit-for-project plasmid vectors.-Sequencing validation to make sure zero mutation, -Competitive price APPlications -Production of viral particles by packaging viral-based plasmid vectors-Generation of immortalized cell line References [1] Liu W., Yin Y., Wang J., Shi B., Zhang L., Qian D., Li C., Zhang H., Wang S., Zhu J., Gao L., Zhang Q., Jia B., et al Kras mutations increase telomerase activity and targeting telomerase is a promising therapeutic strategy for Kras-mutant NSCLC. Oncotarget. 2017; 8: 179-190.[2] Tan M, Li H, Sun Y. Inactivation of Sag/Rbx2/Roc2 e3 ubiquitin ligase triggers senescence and inhibits kras-induced immortalization. Neoplasia. 2015 Jan;17(1):114-23. [3] Muraki N, Yamada M, Doki H, Nakai R, Komeda K, Goto D, Kawabe N, Matsuoka K, Matsushima M, Kawabe T, Tanaka I, Morise M, Shay JW, Minna JD, Sato M. Resistance to mutant KRASV12-induced senescence in an hTERT/Cdk4-immortalized normal human bronchial epithelial cell line. Exp Cell Res. 2022 May 1;414(1):113053. |
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