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| Home -> Products & Services -> Cell Immortalization Plasmid Vectors -> MYC Expression Plasmid Vector | ||
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MYC Expression Plasmid Vector Item No.: PIM-011Shipping: 4 μg Storage: -20°C MYC proto-oncogene, bHLH transcription factor (MYC), also known as MRTL, MYCC, c-Myc, bHLHe39 in human, is a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. MYC forms a heterodimeric complex with the protein MAX and this complex can regulate a variety of known target genes. Deregulated expression of MYC occurs in numerous human cancers indicating its key roles in tumor progression. For several decades, MYC has been widely and successfully used as a means to induce immortalization of various types of primary cells. RGBiotech provides various types of plasmid vectors expressing human or mouse MYC to assist your scientific research work in the field of primary cell immortalization. Please contact us for more product information as well as the price. Highlights -Our large collection of empty vector backbones can always allow you to find the fit-for-project plasmid vectors.-Sequencing validation to make sure zero mutation, -Competitive price APPlications -Production of viral particles by packaging viral-based plasmid vectors-Generation of immortalized cell line References [1] Gil J, Kerai P, Lleonart M, Bernard D, Cigudosa JC, Peters G, Carnero A, Beach D. Immortalization of primary human prostate epithelial cells by c-Myc. Cancer Res. 2005 Mar 15;65(6):2179-85.[2] De Filippis L, Ferrari D, Rota Nodari L, Amati B, Snyder E, Vescovi AL. Immortalization of human neural stem cells with the c-myc mutant T58A. PLoS One. 2008 Oct 2;3(10):e3310. [3] Hirose S, Takayama N, Nakamura S, Nagasawa K, Ochi K, Hirata S, Yamazaki S, Yamaguchi T, Otsu M, Sano S, Takahashi N, Sawaguchi A, Ito M, Kato T, Nakauchi H, Eto K. Immortalization of erythroblasts by c-MYC and BCL-XL enables large-scale erythrocyte production from human pluripotent stem cells. Stem Cell Reports. 2013 Dec 5;1(6):499-508. [4] Bartlett, PF, Reid, HH, Bailey, KA, and Bernard, O (1988). Immortalization of Mouse Neural Precursor Cells by the C-Myc Oncogene. Proceedings of the National Academy of Sciences of the United States of America 85 (9) 3255-3259. |
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