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| Home -> Products & Services -> Cell Immortalization Plasmid Vectors -> [SV40 Small/Large T Antigen] Expression Plasmid Vector | ||
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[SV40 Small/Large T Antigen] Expression Plasmid Vector Item No.: PIM-001Shipping: 4 μg Storage: -20°C Simian Virus 40 (SV40) large T is known to inactivate Rb through p53 leading to immortalization through cell cycle regulation. In most cases, expression of SV40 Large T antigen is sufficient to induce transformation in multiple types of primary cells. Small T Antigen could help Large T antigen to transform some cell types in certain circumstances, and in some cases expression of Small T Antigen by itself is sufficient to cause a transformed phenotype. RGBiotech provides various types of plasmid vectors co-expressing SV40 Small and Large T Antigens to assist your scientific research work in the field of primary cell immortalization. Please contact us for more product information as well as the price. Highlights -Our large collection of empty vector backbones can always allow you to find the fit-for-project plasmid vectors.-Sequencing validation to make sure zero mutation, -Competitive price APPlications -Production of viral particles by packaging viral-based plasmid vectors-Generation of immortalized cell line References [1] Porrás A, Gaillard S, Rundell K. The simian virus 40 small-t and large-T antigens jointly regulate cell cycle reentry in human fibroblasts. J Virol. 1999 Apr;73(4):3102-7.[2] Zhu JY, Abate M, Rice PW, Cole CN. The ability of simian virus 40 large T antigen to immortalize primary mouse embryo fibroblasts cosegregates with its ability to bind to p53. J Virol. 1991 Dec;65(12):6872-80. [3] Yu J, Boyapati A, Rundell K. Critical role for SV40 small-t antigen in human cell transformation. Virology. 2001 Nov 25;290(2):192-8. |
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